BioMed Research International / 2014 / Article / Tab 2 / Research Article
Benchmarking B-Cell Epitope Prediction with Quantitative Dose-Response Data on Antipeptide Antibodies: Towards Novel Pharmaceutical Product Development Table 2 IEDB B-cell assay record counts of selection in Figure
1 .
Method/technique Total Positive Negative Ab-dependent Phagocytosis/opsonization 162 120 42 Antibody-dependent cellular cytotoxicity 42 34 8 Complement-dependent cytotoxicity 63 34 29 Enhancement/activation of antigen activity 21 10 11 Exacerbation of disease after treatment 185 93 92 Hypersensitivity 20 14 6 Ig-mediated histamine release 8 7 1 Induction of tolerance 66 51 15 Inhibition of Ab biological activity 17 12 5 Neutralization/inhibition of antigen activity 1995 1337 658 Protection after challenge 858 499 359 Protection from fertility 79 50 29 Reduction of disease after treatment 125 96 29 Survival after challenge 325 211 114 All of the above methods/techniques 3966 2568 1398