The Sirtuin 3 Expression Profile Is Associated with Pathological and Clinical Outcomes in Colon Cancer Patients
Figure 4
SIRT3 regulates colon cancer cells proliferation, migration, invasion, and apoptosis. Transfection of si-SIRT3 resulted in decreased cell proliferation (a), migration (b), and invasion (c) in the SW 480 and DLD-1 cells. In contrast to the above mentioned changes, the apoptosis was dramatically increased by SIRT3 inhibition in two cell lines (d).
(a) Cell proliferation rates indicated by A562 absorbance
