PET Radiopharmaceuticals for Imaging Integrin Expression: Tracers in Clinical Studies and Recent Developments
Figure 8
Cystine knot based tracer: (a) R01 and S02 are cystine knot peptides that contain 3 disulfide bonds, an active binding loop (black), and a sole primary amine at N terminus used for labeling via 18F-SFB. Peptide sequences are presented with conserved residues highlighted. (b) 18F-fluorobenzoate-R01 small-animal PET imaging of BxPC3 pancreatic adenocarcinoma (integrin -positive) bearing nude mice (five-minute static scans were acquired at 0.5, 1, and 2 h p.i.; decay-corrected coronal and transverse slices are presented; tumor (T) and kidneys (K) are marked on images) (with permission from Hackel et al. [24]).
