Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 872984, 12 pages
Review Article

New Progress in Angiogenesis Therapy of Cardiovascular Disease by Ultrasound Targeted Microbubble Destruction

1Laboratory of Ultrasound Molecular Imaging, Department of Ultrasound Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou 510150, China
2Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong

Received 13 February 2014; Accepted 26 March 2014; Published 12 May 2014

Academic Editor: Yongdoo Choi

Copyright © 2014 Yang-Ying Liao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Angiogenesis plays a vital part in the pathogenesis and treatment of cardiovascular disease and has become one of the hotspots that are being discussed in the past decades. At present, the promising angiogenesis therapies are gene therapy and stem cell therapy. Besides, a series of studies have shown that the ultrasound targeted microbubble destruction (UTMD) was a novel gene delivery system, due to its advantages of noninvasiveness, low immunogenicity and toxicity, repeatability and temporal and spatial target specificity; UTMD has also been used for angiogenesis therapy of cardiovascular disease. In this review, we mainly discuss the combination of UTMD and gene therapy or stem cell therapy which is applied in angiogenesis therapy in recent researches, and outline the future challenges and good prospects of these approaches.