BioMed Research International / 2014 / Article / Tab 1

Review Article

Alpha-Melanocyte Stimulating Hormone: An Emerging Anti-Inflammatory Antimicrobial Peptide

Table 1

Major host defense peptides from humans and their sequences.

AMPs/structureSite of expressionSequenceReferences

α-Defensin, HNP1/β-sheet (3 s-s bonds)Leukocytes, neutrophilsACYCRIPACIAGERR
YGTCIYQGRLWAFC
C
[21, 22]
α-Defensin, HNP2/β-sheet (3 s-s bonds)Leukocytes
Neutrophils
CYCRIPACIAGERRY
GTCIYQGRLWAFCC
[22, 27]
Human α-defensin, HNP3/β-sheet (3 s-s bonds)Leukocytes
Neutrophils
DCYCRIPACIAGERR
YGTCIYQGRLWAFC
C
[8, 22, 27]
Human α-defensin
HNP4/β-sheet (3 s-s bonds)
Leukocytes
Neutrophils
VCSCRLVFCRRTELR
VGNCLIGGVSFTYCC
TRV
[22, 28]
Human α-defensin, HD5/β-sheet (3 s-s bonds)Intestinal tract, vaginal tract (paneth cells)ATCYCRHGRCATRE
SLSGVCEISGRLYRL
CCR
[22, 24]
Human α-defensin, HD6/β-sheet (3 s-s bonds)Intestinal tract (paneth cells)AFTCHCRRSCYSTEY
SYGTCTVMGINHRFC
CL
[22, 24]
Human β-defensin,
HBD1/β-sheet (3 s-s bonds)
Keratinocytes epithelium and mucous lining, salivary and mammary glandDHYNCVSSGGQCLY
SACPIFTKIQGTCYRG
KACCK
[24, 28]
Human β-defensin,
HBD2/β-sheet (3 s-s bonds)
Epithelium, GIT, keratinocytesTCLKSGAICHPVFCP
RRYKQIGTCGLPGTK
CCKKP
[27, 28]
Human β-defensin
HBD3/β-sheet (3 s-s bonds)
GIT, keratinocytes
respiratory tract
GIINTLQKYYCRVRG
GRCAVLSCLPKEEQI
GKCSTRGRKCCRRK
K
[27, 28]
Human β-defensin
HBD4/β-sheet (3 s-s bonds)
Epithelium, GIT, keratinocytesMQRLVLLLAVSLLL
YQDLPVRSEFELDRI
CGYGTARCRKKCRS
QEYRIGRCPNTYACC
LRKWDESLLNRTKP
[27, 28]
Cathelicidin LL-37/hCAP-18
Linear, α-helical
Epithelium, neutrophils, keratinocytes, monocytesLLGDFFRKSKEKIGK
EFKRIVQRIKDFLRNL
VPRTES
[8, 21, 25]
Histatin-5/histidine rich linear, non-α-helicalSalivary glandDSHAKRHHGYKRKF
HEKHHSHRGY
[8]
Lactoferrin
linear
Lactoferrin proteinGRRRRSVQWCAVSQ
PEATKCFQWQRNMR
RVRGPPVSCIKRDSPI
QCIQA
[28]
Hepcidin
Β-sheet, 4 s-s bonds
LiverDTHFPICIFCCGCCHR
SKCGMCCKT
[8]

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