SPECT- and PET-Based Approaches for Noninvasive Diagnosis of Acute Renal Allograft Rejection

Figure 1

A series of PET images of dynamic whole-body acquisitions 180 min after a single tail vein injection of ¹⁸F-FDG into an allogeneically kidney-transplanted rat on postoperative day 4 (POD4). After development of acute rejection (the allograft shows an intense ¹⁸F-FDG uptake on POD4) the recipient was treated with cyclosporine A showing already 24 h after commencement of immunosuppressive therapy a significant decrease of the ¹⁸F-FDG uptake into the renal parenchyma (≜ therapy response). Please note that urine in the renal pelvis can contain eliminated ¹⁸F-FDG. Therefore, it should be excluded from the assessments. Renal graft is marked with yellow circle. % ID: % of injected dose. The figure was adapted from Reuter et al. [28].