SPECT- and PET-Based Approaches for Noninvasive Diagnosis of Acute Renal Allograft Rejection

Figure 2

Exemplary PET images (day 4 after surgery) of dynamic whole-body acquisitions of allogeneically (aTX) and syngeneically transplanted (sTX) rats, rats with ATN (IRI), and rats with acute cyclosporine toxicity (CSA). Effects are summarized after tail vein injection of ¹⁸F-FDG—labeled T cells (maximum-intensity projection, whole-body acquisition for 20 min at 60 min (50–70 min after injection). On postoperative day 4 aTX kidneys exhibited significantly elevated ¹⁸F-FDG uptake in comparison to native controls. Accumulation of labelled cells in kidneys with IRI or acute CSA toxicity and sTX was not significantly different from native controls. Please note that the renal pelvis can contain eliminated ¹⁸F-FDG/¹⁸F-fluoride. Therefore, it has to be excluded from the measurements. ID: injected dose. The figure was taken from Grabner et al. [44].