Butylidenephthalide Blocks Potassium Channels and Enhances Basal Tension in Isolated Guinea-Pig Trachea

Figure 3

Log concentration relaxant (a) and contractile (b) response curves of butylidenephthalide (Bdph) in isolated guinea-pig trachea. The relaxant and contractile effects of cumulative Bdph (30~1000 μM) on histamine (10 μM)-induced precontraction and on baseline tension were performed as method described, respectively. All values are shown as mean ± SEM, and 𝑛 is the number of experiments. ^∗𝑃<0.05, ^∗∗𝑃<0.01, and ^∗∗∗𝑃<0.001 compared to its vehicle.

(a)

(b)