Determinants of Disability in Multiple Sclerosis: An Immunological and MRI Study

Table 2

Conventional and DT MRI findings from HC and all MS patients.

	HC (𝑛=37)	All MS (𝑛=59)	HC versus MS
LV	—	16.5 (15.5)	—
NBV	1531.3 (78.1)	1462.2 (91.2)	<0.001
NCV	624.0 (48.4)	577.8 (74.6)	<0.0001
NGMV	790.6 (55.2)	722.9 (95.4)	<0.0001
NWMV	737.6 (36.7)	739.2 (39.2)	<0.001
Left CST FA	0.515 (0.038)	0.490 (0.050)	0.016
Left CST MD	0.727 (0.029)	0.736 (0.051)	ns
Right CST FA	0.496 (0.024)	0.459 (0.039)	<0.001
Right CST MD	0.749 (0.026)	0.762 (0.053)	ns

Data are reported as mean (standard deviations). 𝑃 values from group comparisons (𝑡-test) are reported. Lesion and tissue volumes are expressed in cc, MD is expressed in 10⁻³ mm² s⁻¹, and FA is a dimensionless index.
LV: total brain lesion volume; NBV: normalized brain volume; NCV: normalized cortical grey matter volume; NGMV: normalized grey matter volume; NWMV: normalized white matter volume; CST: corticospinal tract; MD: mean diffusivity; FA: fractional anisotropy; ns: not significant.
See the text for other abbreviations and statistical analysis details.