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BioMed Research International
Volume 2014 (2014), Article ID 890675, 7 pages
http://dx.doi.org/10.1155/2014/890675
Research Article

The Effect of Hypoxia on the Stemness and Differentiation Capacity of PDLC and DPC

Yinghong Zhou,1,2 Wei Fan,3 and Yin Xiao1,2,3

1Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD 4059, Australia
2Australia-China Centre for Tissue Engineering and Regenerative Medicine (ACCTERM), Brisbane, QLD 4059, Australia
3The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan 430079, China

Received 14 November 2013; Accepted 8 January 2014; Published 20 February 2014

Academic Editor: Jiang Chang

Copyright © 2014 Yinghong Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. A. Reynolds, M. E. Aichelmann-Reidy, and G. L. Branch-Mays, “Regeneration of periodontal tissue: bone replacement grafts,” Dental Clinics of North America, vol. 54, no. 1, pp. 55–71, 2010. View at Publisher · View at Google Scholar · View at Scopus
  2. J. Lee, A. Stavropoulos, C. Susin, and U. M. E. Wikesjö, “Periodontal regeneration: focus on growth and differentiation factors,” Dental Clinics of North America, vol. 54, no. 1, pp. 93–111, 2010. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Skrtic and J. M. Antonucci, “Bioactive polymeric composites for tooth mineral regeneration: physicochemical and cellular aspects,” Journal of Functional Biomaterials, vol. 2, no. 3, pp. 271–307, 2011. View at Publisher · View at Google Scholar
  4. H. Zhang, S. Liu, Y. Zhou et al., “Natural mineralized scaffolds promote the dentinogenic potential of dental pulp stem cells via the mitogen-activated protein kinase signaling pathway,” Tissue Engineering A, vol. 18, no. 7-8, pp. 677–691, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. T. Nakahara, “Potential feasibility of dental stem cells for regenerative therapies: stem cell transplantation and whole-tooth engineering,” Odontology, vol. 99, no. 2, pp. 105–111, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. H. Ikeda, Y. Sumita, M. Ikeda et al., “Engineering bone formation from human dental pulp- and periodontal ligament-derived cells,” Annals of Biomedical Engineering, vol. 39, no. 1, pp. 26–34, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Liu, X. Wei, J. Ling, L. Wu, and Y. Xiao, “Expression pattern of Oct-4, sox2, and c-Myc in the primary culture of human dental pulp derived cells,” Journal of Endodontics, vol. 37, no. 4, pp. 466–472, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. Y. Sawa, A. Phillips, J. Hollard, S. Yoshida, and M. W. Braithwaite, “The in vitro life-span of human periodontal ligament fibroblasts,” Tissue and Cell, vol. 32, no. 2, pp. 163–170, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. B. J. Moxham, P. P. Webb, M. Benjamin, and J. R. Ralphs, “Changes in the cytoskeleton of cells within the periodontal ligament and dental pulp of the rat first molar tooth during ageing,” European Journal of Oral Sciences, vol. 106, supplement 1, pp. 376–383, 1998. View at Google Scholar · View at Scopus
  10. D. Jing, M. Wobus, D. M. Poitz, M. Bornhäuser, G. Ehninger, and R. Ordemann, “Oxygen tension plays a critical role in the hematopoietic microenvironment in vitro,” Haematologica, vol. 97, no. 3, pp. 331–339, 2012. View at Publisher · View at Google Scholar · View at Scopus
  11. A. Mohyeldin, T. Garzón-Muvdi, and A. Quiñones-Hinojosa, “Oxygen in stem cell biology: a critical component of the stem cell niche,” Cell Stem Cell, vol. 7, no. 2, pp. 150–161, 2010. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Mazumdar, V. Dondeti, and M. C. Simon, “Hypoxia-inducible factors in stem cells and cancer,” Journal of Cellular and Molecular Medicine, vol. 13, no. 11-12, pp. 4319–4328, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. J. D. Webb, M. L. Coleman, and C. W. Pugh, “Hypoxia, hypoxia-inducible factors (HIF), HIF hydroxylases and oxygen sensing,” Cellular and Molecular Life Sciences, vol. 66, no. 22, pp. 3539–3554, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. G. L. Semenza, “Regulation of metabolism by hypoxia-inducible factor 1,” Cold Spring Harbor Symposia on Quantitative Biology, vol. 76, pp. 347–353, 2011. View at Publisher · View at Google Scholar
  15. J. Milosevic, S. C. Schwarz, K. Krohn, M. Poppe, A. Storch, and J. Schwarz, “Low atmospheric oxygen avoids maturation, senescence and cell death of murine mesencephalic neural precursors,” Journal of Neurochemistry, vol. 92, no. 4, pp. 718–729, 2005. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Vlaski, X. Lafarge, J. Chevaleyre, P. Duchez, J. Boiron, and Z. Ivanovic, “Low oxygen concentration as a general physiologic regulator of erythropoiesis beyond the EPO-related downstream tuning and a tool for the optimization of red blood cell production ex vivo,” Experimental Hematology, vol. 37, no. 5, pp. 573–584, 2009. View at Publisher · View at Google Scholar · View at Scopus
  17. I. Szablowska-Gadomska, V. Zayat, and L. Buzanska, “Influence of low oxygen tensions on expression of pluripotency genes in stem cells,” Acta Neurobiologiae Experimentalis, vol. 71, no. 1, pp. 86–93, 2011. View at Google Scholar · View at Scopus
  18. S. D. Westfall, S. Sachdev, P. Das et al., “Identification of oxygen-sensitive transcriptional programs in human embryonic stem cells,” Stem Cells and Development, vol. 17, no. 5, pp. 869–881, 2008. View at Publisher · View at Google Scholar · View at Scopus
  19. K. Takahashi and S. Yamanaka, “Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors,” Cell, vol. 126, no. 4, pp. 663–676, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Yu, M. A. Vodyanik, K. Smuga-Otto et al., “Induced pluripotent stem cell lines derived from human somatic cells,” Science, vol. 318, no. 5858, pp. 1917–1920, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Liu, J. Ling, X. Wei, L. Wu, and Y. Xiao, “Stem cell regulatory gene expression in human adult dental pulp and periodontal ligament cells undergoing odontogenic/osteogenic differentiation,” Journal of Endodontics, vol. 35, no. 10, pp. 1368–1376, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. K. A. Webster, “Regulation of glycolytic enzyme RNA transcriptional rates by oxygen availability in skeletal muscle cells,” Molecular and Cellular Biochemistry, vol. 77, no. 1, pp. 19–28, 1987. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. Zhou, N. Chakravorty, Y. Xiao, and W. Gu, “Mesenchymal stem cells and nano-structured surfaces,” Methods in Molecular Biology, vol. 1058, pp. 133–148, 2013. View at Publisher · View at Google Scholar
  24. J. Rehman, “Empowering self-renewal and differentiation: the role of mitochondria in stem cells,” Journal of Molecular Medicine, vol. 88, no. 10, pp. 981–986, 2010. View at Publisher · View at Google Scholar · View at Scopus
  25. A. M. Singh and S. Dalton, “The cell cycle and Myc intersect with mechanisms that regulate pluripotency and reprogramming,” Cell Stem Cell, vol. 5, no. 2, pp. 141–149, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Mathieu, Z. Zhang, W. Zhou et al., “HIF induces human embryonic stem cell markers in cancer cells,” Cancer Research, vol. 71, no. 13, pp. 4640–4652, 2011. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Bentovim, R. Amarilio, and E. Zelzer, “HIF1α is a central regulator of collagen hydroxylation and secretion under hypoxia during bone development,” Development, vol. 139, no. 23, pp. 4473–4483, 2012. View at Publisher · View at Google Scholar
  28. W. L. Grayson, F. Zhao, B. Bunnell, and T. Ma, “Hypoxia enhances proliferation and tissue formation of human mesenchymal stem cells,” Biochemical and Biophysical Research Communications, vol. 358, no. 3, pp. 948–953, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. H. H. Lee, C. C. Chang, M. J. Shieh et al., “Hypoxia enhances chondrogenesis and prevents terminal differentiation through PI3K/Akt/FoxO dependent anti-apoptotic effect,” Scientific Reports, vol. 3, article 2683, 2013. View at Publisher · View at Google Scholar
  30. S. He, P. Liu, Z. Jian et al., “miR-138 protects cardiomyocytes from hypoxia-induced apoptosis via MLK3/JNK/c-jun pathway,” Biochemical and Biophysical Research Communications, vol. 441, no. 4, pp. 763–769, 2013. View at Publisher · View at Google Scholar
  31. V. K. Bhaskara, I. Mohanam, J. S. Rao, and S. Mohanam, “Intermittent hypoxia regulates stem-like characteristics and differentiation of neuroblastoma cells,” PLoS ONE, vol. 7, no. 2, Article ID e30905, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. D. C. Genetos, C. M. Lee, A. Wong, and C. E. Yellowley, “HIF-1α regulates hypoxia-induced EP1 expression in osteoblastic cells,” Journal of Cellular Biochemistry, vol. 107, no. 2, pp. 233–239, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. L. Li, Y. Zhu, L. Jiang, W. Peng, and H. H. Ritchie, “Hypoxia promotes mineralization of human dental pulp cells,” Journal of Endodontics, vol. 37, no. 6, pp. 799–802, 2011. View at Publisher · View at Google Scholar · View at Scopus