Expression of Myeloid Antigen in Neoplastic Plasma Cells Is Related to Adverse Prognosis in Patients with Multiple Myeloma
Table 2
Comparison of clinical data in groups positive and negative for CD33 and CD13.
Clinical parameters
CD33 Mean or number (%)
CD13 Mean or number (%)
Negative
Positive
Negative
Positive
Age
61.2
61.1
0.978
61.9
60.4
0.688
Calcium (mg/dL)
9.03
9.78
0.049
9.03
9.60
0.145
Creatinine (mg/dL)
1.36
1.28
0.710
1.32
1.50
0.434
Albumin (mg/dL)
3.81
3.55
0.270
3.66
3.91
0.243
β2-Microglobulin (mg/dL)
4.76
4.71
0.966
3.09
4.28
0.635
Hemoglobin (g/dL)
10.6
9.8
0.277
10.3
10.6
0.687
LDH (U/L)
172
369
0.018
140
302
0.078
Monoclonal heavy chain
0.793
0.454
IgG
24 (77)
7 (23)
12 (60)
8 (40)
IgA
10 (91)
1 (9)
2 (29)
5 (71)
IgD
3 (100)
0 (0)
1 (33)
2 (67)
Light chain only
7 (29)
2 (71)
3 (38)
5 (52)
Monoclonal light chain
0.603
0.207
Kappa
27 (82)
6 (18)
9 (39)
14 (61)
Lambda
17 (81)
4 (9)
9 (60)
6 (40)
BM aspirate plasma cell (%)
38
48
0.903
36
48
0.198
Plasma cell type
0.022
0.519
Mature
35 (90)
4 (10)
14 (54)
12 (46)
Immature
4 (50)
4 (50)
2 (29)
5 (71)
Plasmablastic
1 (50)
1 (50)
0 (0)
1 (100)
Pleomorphic
4 (80)
1 (20)
2 (50)
2 (50)
Infiltration pattern
0.487
0.046
Interstitial
14 (88)
2 (12)
5 (100)
0 (0)
Focal
2 (67)
1 (33)
1 (50)
1 (50)
Diffuse
28 (80)
7 (20)
12 (44)
15 (56)
Cytogenetics (FISH)‡
t(4;14)
7/40
1/4
0.566
3/18
4/19
0.532
1q amplification
14/39
4/7
0.258
6/18
9/19
0.297
13q deletion
14/39
4/7
0.258
5/18
8/19
0.286
17p deletion
2/33
0/7
0.677
0/15
2/15
0.241
Cytogenetic high risk group
9/35
1/7
0.461
3/16
6/16
0.217
International staging system
0.742
0.647
Stage I
19 (86)
3 (14)
6 (43)
8 (57)
Stage II
14 (78)
4 (22)
6 (43)
8 (57)
Stage III
11 (79)
3 (21)
6 (60)
4 (40)
Durie-Salmon stage
0.753
0.766
Stage I
5 (100)
0 (0)
2 (67)
1 (33)
Stage II
9 (82)
2 (18)
3 (38)
5 (62)
Stage III
30 (77)
9 (23)
13 (48)
14 (52)
IMWG risk
0.867
0.791
Low
8 (82)
1 (18)
3 (60)
2 (40)
Standard
30 (79)
8 (21)
12 (46)
14 (54)
High
6 (86)
1 (14)
3 (43)
4 (47)
IMWG response
0.742
0.698
Complete response
8 (80)
2 (20)
4 (50)
4 (50)
Very good partial response
6 (86)
1 (14)
2 (40)
3 (60)
Partial response
10 (83)
2 (17)
5 (71)
2 (29)
Stable disease
1 (50)
1 (50)
1 (100)
0 (0)
Progressive disease
5 (71)
2 (29)
3 (43)
4 (57)
BM: bone marrow; LDH: lactate dehydrogenase; IMWG: International Myeloma Working Group; ‡numbers of positive cases among FISH tests done; percentages were not written because meanings were different from that of other parameters; including t(4;14) or del(17p).
