Table 2: Selected blood- and lung-targeting microRNAs and their validated or predicted target genes.

microRNATarget genes

TB versus control downregulated
 hsa-let-7i-5p ADM, HMGA2, LRRK2, SERPING1, TLR4
LTBI versus control upregulated
 hsa-miR-107BTG2,  EIF5
 hsa-miR-142-3pa,bKLF4,  POMC,  JUN,  PMAIP1,  PDGFRB,  SIK1
 hsa-miR-16-5pSIK1,  NR4A1,  IER2,  AGPAT4,  CSRNP1,  PLEKHG2,  CD69
 hsa-miR-21-5pbCD69,  H3F3B,  TAF1C,  TRIB1,  PMAIP1
 hsa-miR-22-3pH3F3B,  TAF1C,  TRIB1,  PMAIP1,  BTG2
 hsa-miR-221-3pFOS,  ZBTB24,  EIF1,  MYLIP,  NAP1L5,  SOCS3
 hsa-miR-223-3pbRHOB,  CXCL2
LTBI versus TB upregulated
 hsa-miR-146a-5pbST20
 hsa-miR-150-5pbCPD,  ARRB2,  FFAR2,  NUP214,  PNMA3,  C20orf24,  C16orf57
 hsa-miR-16-5pCPD,  C15orf39,  C16orf57,  TUBA1A
 hsa-miR-221-3pANXA1,  FOS,  PLAUR,  TIMP2,  C16orf57,  MIDN

validated microRNA-target interaction; bindicates that these microRNAs have been implicated in tuberculosis.