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BioMed Research International
Volume 2014, Article ID 895401, 9 pages
Research Article

Hypervolemia for Hypertension Pathophysiology: A Population-Based Study

1Division of Nephrology, Bülent Ecevit University, Zonguldak, Turkey
2Department of Internal Medicine, Ege University, Izmir, Turkey
3Nephrology Clinic, Ataturk State Hospital, Zonguldak, Turkey
4Nephrology Clinic, Istanbul Education and Research Hospital, Istanbul, Turkey
5Department of Biostatistics, Bülent Ecevit University, Zonguldak, Turkey
6Division of Nephrology, Akdeniz University, Antalya, Turkey
7Division of Nephrology, Ankara University, Ankara, Turkey

Received 5 February 2014; Revised 26 June 2014; Accepted 30 June 2014; Published 11 August 2014

Academic Editor: Abbas Dehghan

Copyright © 2014 Ender Hür et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objectives. Hypertension and hypervolemia relationship was proven among renal disease, although it is not known in normal population. Present study determines the fluid distribution defects in relation to blood pressure. Material and Methods. In a population-based survey in Turkey demographics, height, weight, blood pressure, urine analysis, and serum creatinine measurements were recorded. Bioimpedance measured with the Body Composition Monitor. Results. Total 2034 population of 71.6% male, mean age 47 ± 12.6 (18–89) years, systolic blood pressure (SBP) 134.7 ± 20, diastolic blood pressure 77.9 ± 11.6 mmHg. Body mass index (BMI) was 28.5 ± 4.5 (15.8–50.6) kg/m2; overhydration was 0.05 ± 1.05 L. There was a correlation between extracellular water (ECW)/height and SBP (r = 0.21, P < 0.001). Receiver operating characteristic (ROC) curve with the performance of 0.60 (P < 0.001) that showed cut-off value of ECW/height was 10.06 L/m, with the 69% sensitivity and 45% specificity for SBP: 140 mmHg values. Risk factors for high SBP were increase of ECW/Height, age, BMI and presence of diabetes. ECW/height, SBP, and fat tissue index (FTI) increased in BMI categories (low, normal, and obese) and in diabetics. SBP and FTI were lower in smokers. Conclusions. High blood pressure may be accompanied by increased extracellular volume indices. In the future volume status assessment could be of use in evaluating the effectiveness of pharmacological intervention in the treatment of hypertension.