Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy

Figure 4

Simulations of typical free and total cefazolin concentration-time profiles using the empirical and the semiphysiological approach at different periods of pregnancy (gestational weeks) based on a dose regimen of 2 g cefazolin every 6 or 8 hours administered over 30 minutes. The expected 90% minimum inhibitory concentration is depicted as horizontal black line. GW: gestational weeks.