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BioMed Research International
Volume 2014, Article ID 897216, 9 pages
http://dx.doi.org/10.1155/2014/897216
Research Article

Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy

1Department of Clinical Pharmacology, Netherlands Cancer Institute, Plesmanlaan 121, P.O. Box 1066 CX, Amsterdam, The Netherlands
2Department of Pharmacy & Pharmacology, Netherlands Cancer Institute/Slotervaart Hospital, Louwesweg 6, P.O. Box 90440, 1006 BK Amsterdam, The Netherlands
3Department of Development and Regeneration, KU Leuven, Herestraat 49, 300 Leuven, Belgium
4Neonatal Intensive Care Unit, University Hospitals Leuven, Herestraat 49, 300 Leuven, Belgium
5Obstetrics and Gynecology, University Hospitals Leuven, Herestraat 49, 300 Leuven, Belgium
6Division of Pharmacoepidemiology & Clinical Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, P.O. Box 80125, 3508 TC Utrecht, The Netherlands

Received 2 October 2013; Revised 10 December 2013; Accepted 18 December 2013; Published 3 February 2014

Academic Editor: Stephanie Laër

Copyright © 2014 J. G. Coen van Hasselt et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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