BioMed Research International / 2014 / Article / Tab 3

Research Article

Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy

Table 3

Parameter estimates of the nonlinear mixed effect model for change in creatinine clearance (CrCL).

DescriptionParameterUnitEstimates (RSE%)

Structural model estimates as reported in a previous meta-analysis (13)
Baseline CrCL mL/min97.83 (3.91)*
Maximum CrCL 83.83 (12.48)*
Time of half-maximum CrCL weeks13.3 (37.59)*

Between subject variability (CV%)
Baseline CrCL CV%31.4 (16)
Maximum CrCL CV%35.1 (17)
Time of half-maximum CrCL CV%111.8 (121)

Residual unexplained variability variance
Proportional error 0.0291 (43)

CrCL: creatinine clearance; RSE: relative standard error. These values were fixed during estimation of the mixed effect model; that is, only random effects were estimated.

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