Semiphysiological versus Empirical Modelling of the Population Pharmacokinetics of Free and Total Cefazolin during Pregnancy
Table 3
Parameter estimates of the nonlinear mixed effect model for change in creatinine clearance (CrCL).
Description
Parameter
Unit
Estimates (RSE%)
Structural model estimates as reported in a previous meta-analysis (13)
Baseline CrCL
mL/min
97.83 (3.91)*
Maximum CrCL
—
83.83 (12.48)*
Time of half-maximum CrCL
weeks
13.3 (37.59)*
Between subject variability (CV%)
Baseline CrCL
CV%
31.4 (16)
Maximum CrCL
CV%
35.1 (17)
Time of half-maximum CrCL
CV%
111.8 (121)
Residual unexplained variability variance
Proportional error
0.0291 (43)
CrCL: creatinine clearance; RSE: relative standard error. These values were fixed during estimation of the mixed effect model; that is, only random effects were estimated.
