Trichinella spiralis Excretory-Secretory Products Protect against Polymicrobial Sepsis by Suppressing MyD88 via Mannose Receptor

Figure 2

TsES reduced the inflammatory response and enhanced bacterial clearance. Serum TNF-α, IL-1β, IL-6, HMGB1, IL-10, and TGFβ1 levels in mice 12 h after the operation were measured by ELISA (a). Mouse peritoneal neutrophils and monocytes were counted 4 h, 12 h, and 24 h after the CLP or sham operation (b). Peritoneal lavage fluid (c) and blood (d) obtained 4 h and 24 h after the CLP operation were cultured on agar plates and the bacterial colonies were counted. Data are expressed as means ± SD. ^∗∗𝑃<0.05 compared to the PBS + sham group. ^∗𝑃<0.05 compared to the PBS + CLP group. ^#𝑃<0.05 compared to the TsES + CLP group.

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