Nucleobase-Based Barbiturates: Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay

<table>Synthesis of DNA base and heterocyclic primary amines-based barbiturates. Reagents and conditions: (a) NaOMe/MeOH-refluxed (b) HCO<sub>2</sub>H, water, reflux, where R1 = adenine, guanine, cytosine, and primary heterocyclic amine.</table>

BioMed Research International

sch1

Scheme 1

Scheme 1: Nucleobase-Based Barbiturates: Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay 

Scheme 1 | Nucleobase-Based Barbiturates: Their Protective Effect against DNA Damage Induced by Bleomycin-Iron, Antioxidant, and Lymphocyte Transformation Assay 