Sunitinib Combined with Angiotensin-2 Type-1 Receptor Antagonists Induces More Necrosis: A Murine Xenograft Model of Renal Cell Carcinoma

<table>Combination significantly increases tumor necrosis but not sunitinib alone. (a) Histological analysis of tumors by HES staining (×200) reveals Fuhrman 4 ccRCC (A). Tumor necrosis (•) evaluated by HES staining (×20) in tumor from control group (B) and tumor from combination of sunitinib and telmisartan (C). (b) Quantification of necrosis in tumors from different groups. Mean ± SEM, <svg height="17.825001" id="M14" style="vertical-align:-3.13504pt" version="1.1" viewbox="0 0 69.150002 17.825001" width="69.150002" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink">
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BioMed Research International

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Figure 3

Figure 3: Sunitinib Combined with Angiotensin-2 Type-1 Receptor Antagonists Induces More Necrosis: A Murine Xenograft Model of Renal Cell Carcinoma 