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BioMed Research International
Volume 2014, Article ID 902735, 8 pages
http://dx.doi.org/10.1155/2014/902735
Research Article

Distinct Action of Flavonoids, Myricetin and Quercetin, on Epithelial Cl Secretion: Useful Tools as Regulators of Cl Secretion

1Department of Molecular Cell Physiology Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
2Japan Institute for Food Education and Health, St. Agnes’ University, Kyoto 602-8013, Japan
3Shin-Koiwa Clinic, Tokyo 124-0023, Japan
4Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
5Department of Bio-Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan

Received 25 February 2014; Revised 6 March 2014; Accepted 10 March 2014; Published 10 April 2014

Academic Editor: Akio Tomoda

Copyright © 2014 Hongxin Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [12 citations]

The following is the list of published articles that have cited the current article.

  • Hongxin Sun, Naomi Niisato, Toshio Inui, and Yoshinori Marunaka, “Insulin is involved in transcriptional regulation of NKCC and the CFTR Cl− channel through PI3K activation and ERK inactivation in renal epithelial cells,” The Journal of Physiological Sciences, 2014. View at Publisher · View at Google Scholar
  • Kouhei Sasamoto, Naomi Niisato, Akiyuki Taruno, and Yoshinori Marunaka, “Simulation of Cl− Secretion in Epithelial Tissues: New Methodology Estimating Activity of Electro-Neutral Cl− Transporter,” Frontiers in Physiology, vol. 6, 2015. View at Publisher · View at Google Scholar
  • Ken-ichi Nakajima, and Yoshinori Marunaka, “Intracellular chloride ion concentration in differentiating neuronal cell and its role in growing neurite,” Biochemical and Biophysical Research Communications, 2016. View at Publisher · View at Google Scholar
  • Kwang-Su Park, Youhoon Chong, and Mi Kyoung Kim, “Myricetin: biological activity related to human health,” Applied Biological Chemistry, 2016. View at Publisher · View at Google Scholar
  • Narisato Kanamura, Yoshinori Marunaka, Rie Marunaka, Hongxin Sun, Toshiro Yamamoto, and Akiyuki Taruno, “Na+ homeostasis by epithelial Na+ channel (ENaC) and Nax channel (Nax): Cooperation of ENaC and Nax,” Annals of Translational Medicine, vol. 4, 2016. View at Publisher · View at Google Scholar
  • Yoshinori Marunaka, “The Mechanistic Links between Insulin and Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Cl− Channel,” International Journal of Molecular Sciences, vol. 18, no. 8, pp. 1767, 2017. View at Publisher · View at Google Scholar
  • Yoshinori Marunaka, “Actions of quercetin, a flavonoid, on ion transporters: its physiological roles,” Annals of the New York Academy of Sciences, 2017. View at Publisher · View at Google Scholar
  • Kouhei Sasamoto, Kyosuke Nishio, Yoshinori Marunaka, Rie Marunaka, Naomi Niisato, Hongxin Sun, Toshiro Yamamoto, Narisato Kanamura, Toshio Inui, Douglas C. Eaton, Akiyuki Taruno, Giuseppe Pezzotti, and Wenliang Zhu, “Analysis of aprotinin, a protease inhibitor, action on the trafficking of epithelial Na+ Channels (ENaC) in renal epithelial cells using a mathematical model,” Cellular Physiology and Biochemistry, vol. 41, no. 5, pp. 1865–1880, 2017. View at Publisher · View at Google Scholar
  • Atsushi Shiozaki, Eigo Otsuji, Sachie Tanaka, Hiroaki Miyazaki, Daisuke Ichikawa, and Yoshinori Marunaka, “Cytosolic Cl- affects the anticancer activity of paclitaxel in the gastric cancer cell line, MKN28 Cell,” Cellular Physiology and Biochemistry, vol. 42, no. 1, pp. 68–80, 2017. View at Publisher · View at Google Scholar
  • Yoshinori Marunaka, Rie Marunaka, Hongxin Sun, Toshiro Yamamoto, Narisato Kanamura, Toshio Inui, and Akiyuki Taruno, “Actions of Quercetin, a Polyphenol, on Blood Pressure,” Molecules, vol. 22, no. 2, pp. 209, 2017. View at Publisher · View at Google Scholar
  • Rie Marunaka, Akiyuki Taruno, Toshiro Yamamoto, Yoshinori Marunaka, and Narisato Kanamura, “Action of Protein Tyrosine Kinase Inhibitors on the Hypotonicity-Stimulated Trafficking Kinetics of Epithelial Na+ Channels (ENaC) in Renal Epithelial Cells: Analysis Using a Mathematical Model,” Cellular Physiology and Biochemistry, vol. 50, no. 1, pp. 378–384, 2018. View at Publisher · View at Google Scholar
  • Yoshinori Marunaka, Haruka Kogiso, Takashi Nakahari, Naomi Niisato, Hiroaki Miyazaki, Ken-Ichi Nakajima, Motoki Okui, Narisato Kanamura, Yukiko Ikeuchi, Makiko Kashio, Shigekuni Hosogi, Akiyuki Taruno, Hongxin Sun, Rie Marunaka, and Toshiro Yamamoto, “Quercetin is a useful medicinal compound showing various actions including control of blood pressure, neurite elongation and epithelial ion transport,” Current Medicinal Chemistry, vol. 25, no. 37, pp. 4876–4887, 2018. View at Publisher · View at Google Scholar