Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014 (2014), Article ID 902735, 8 pages
http://dx.doi.org/10.1155/2014/902735
Research Article

Distinct Action of Flavonoids, Myricetin and Quercetin, on Epithelial Cl Secretion: Useful Tools as Regulators of Cl Secretion

1Department of Molecular Cell Physiology Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
2Japan Institute for Food Education and Health, St. Agnes’ University, Kyoto 602-8013, Japan
3Shin-Koiwa Clinic, Tokyo 124-0023, Japan
4Department of Physiology, School of Medical Sciences, University of Otago, Dunedin 9054, New Zealand
5Department of Bio-Ionomics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan

Received 25 February 2014; Revised 6 March 2014; Accepted 10 March 2014; Published 10 April 2014

Academic Editor: Akio Tomoda

Copyright © 2014 Hongxin Sun et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. H. Hong, S. Park, N. Shcheynikov, and S. Muallem, “Mechanism and synergism in epithelial fluid and electrolyte secretion,” Pflügers Archiv, 2013. View at Publisher · View at Google Scholar
  2. Y. Marunaka, “Hormonal and osmotic regulation of NaCl transport in renal distal nephron epithelium,” Japanese Journal of Physiology, vol. 47, no. 6, pp. 499–511, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. J. Asano, N. Niisato, K.-I. Nakajima et al., “Quercetin stimulates Na+/K+/2Cl- cotransport via PTK-dependent mechanisms in human airway epithelium,” American Journal of Respiratory Cell and Molecular Biology, vol. 41, no. 6, pp. 688–695, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Blouquit-Laye and T. Chinet, “Ion and liquid transport across the bronchiolar epithelium,” Respiratory Physiology and Neurobiology, vol. 159, no. 3, pp. 278–282, 2007. View at Publisher · View at Google Scholar · View at Scopus
  5. T. E. Machen, “Innate immune response in CF airway epithelia: hyperinflammatory?” American Journal of Physiology—Cell Physiology, vol. 291, no. 2, pp. C218–C230, 2006. View at Publisher · View at Google Scholar · View at Scopus
  6. K. Sasamoto, N. Niisato, and Y. Marunaka, “Analysis of epithelial ion transport by mathematical model,” Journal of Physiological Sciences, vol. 62, p. S136, 2012. View at Google Scholar
  7. N. Niisato, Y. Ito, and Y. Marunaka, “Activation of Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells by flavonoids: genistein, daidzein, and apigenin,” Biochemical and Biophysical Research Communications, vol. 254, no. 2, pp. 368–371, 1999. View at Publisher · View at Google Scholar · View at Scopus
  8. F. Li, Y. Takahashi, and K. Yamaki, “Inhibitory effect of catechin-related compounds on renin activity,” BioMed Research, vol. 34, no. 3, pp. 167–171, 2013. View at Google Scholar
  9. P.-C. Chao and K. L. Hamilton, “Genistein stimulates electrogenic Cl- secretion via phosphodiesterase modulation in the mouse jejunum,” American Journal of Physiology—Cell Physiology, vol. 297, no. 3, pp. C688–C698, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. N. Niisato, H. Nishino, K. Nishio, and Y. Marunaka, “Cross talk of cAMP and flavone in regulation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel and Na+/K+/2Cl- cotransporter in renal epithelial A6 cells,” Biochemical Pharmacology, vol. 67, no. 4, pp. 795–801, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. G. di Carlo, G. Autore, A. A. Izzo et al., “Inhibition of intestinal motility and secretion by flavonoids in mice and rats: structure-activity relationships,” Journal of Pharmacy and Pharmacology, vol. 45, no. 12, pp. 1054–1059, 1993. View at Google Scholar · View at Scopus
  12. K. C. Ong and H.-E. Khoo, “Biological effects of myricetin,” General Pharmacology, vol. 29, no. 2, pp. 121–126, 1997. View at Publisher · View at Google Scholar · View at Scopus
  13. T. Suzuki and H. Hara, “Role of flavonoids in intestinal tight junction regulation,” Journal of Nutritional Biochemistry, vol. 22, no. 5, pp. 401–408, 2011. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Diener and E. Scharrer, “Effects of short-chain fatty acids on cell volume regulation and chloride transport in the rat distal colon,” Comparative Biochemistry and Physiology—A Physiology, vol. 118, no. 2, pp. 375–379, 1997. View at Publisher · View at Google Scholar · View at Scopus
  15. B. Chen, G. Nicol, and W. K. Cho, “Role of calcium in volume-activated chloride currents in a mouse cholangiocyte cell line,” Journal of Membrane Biology, vol. 215, no. 1, pp. 1–13, 2007. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Niisato and Y. Marunaka, “Activation of the Na+-K+ pump by hyposmolality through tyrosine kinase-dependent Cl- conductance in Xenopus renal epithelial A6 cells,” Journal of Physiology, vol. 518, part 2, pp. 417–432, 1999. View at Publisher · View at Google Scholar · View at Scopus
  17. K. L. Hamilton and D. C. Eaton, “Single-channel recordings from amiloride-sensitive epithelial sodium channel,” The American journal of physiology, vol. 249, no. 3, pp. C200–C207, 1985. View at Google Scholar · View at Scopus
  18. Y. Marunaka, N. Niisato, A. Taruno et al., “Regulation of epithelial sodium transport via epithelial Na+ channel,” Journal of Biomedicine and Biotechnology, vol. 2011, Article ID 978196, 8 pages, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. L. Yu, H. Cai, Q. Yue et al., “WNK4 inhibition of ENaC is independent of Nedd4-2-mediated ENaC ubiquitination,” American Journal of Physiology—Renal Physiology, vol. 305, no. 1, pp. F31–F41, 2013. View at Google Scholar
  20. H. F. Bao, L. Liu, J. Self, B. J. Duke, R. Ueno, and D. C. Eaton, “A synthetic prostone activates apical chloride channels in A6 epithelial cells,” American Journal of Physiology—Gastrointestinal and Liver Physiology, vol. 295, no. 2, pp. G234–G251, 2008. View at Publisher · View at Google Scholar · View at Scopus
  21. T. A. West and B. L. Blazer-Yost, “Modulation of basal and peptide hormone-stimulated Na+ transport by membrane cholesterol content in the A6 epithelial cell line,” Cellular Physiology and Biochemistry, vol. 16, no. 4–6, pp. 263–270, 2005. View at Publisher · View at Google Scholar · View at Scopus
  22. M. A. Shane, C. Nofziger, and B. L. Blazer-Yost, “Hormonal regulation of the epithelial Na+ channel: from amphibians to mammals,” General and Comparative Endocrinology, vol. 147, no. 1, pp. 85–92, 2006. View at Publisher · View at Google Scholar · View at Scopus
  23. M. L. Chalfant, K. Peterson-Yantorno, T. G. O'Brien, and M. M. Civan, “Regulation of epithelial Na+ channels from M-1 cortical collecting duct cells,” American Journal of Physiology—Renal Fluid and Electrolyte Physiology, vol. 271, no. 4, part 2, pp. F861–F870, 1996. View at Google Scholar · View at Scopus
  24. M. M. Civan, K. Peterson-Yantorno, J. Sanchez-Torres, and M. Coca-Prados, “Potential contribution of epithelial Na+ channel to net secretion of aqueous humor,” Journal of Experimental Zoology, vol. 279, no. 5, pp. 498–503, 1997. View at Google Scholar
  25. K. Kunzelmann and M. Mall, “Electrolyte transport in the mammalian colon: mechanisms and implications for disease,” Physiological Reviews, vol. 82, no. 1, pp. 245–289, 2002. View at Google Scholar · View at Scopus
  26. J. Praetorius, “Water and solute secretion by the choroid plexus,” Pflugers Archiv, vol. 454, no. 1, pp. 1–18, 2007. View at Publisher · View at Google Scholar · View at Scopus
  27. H. Sun, N. Niisato, and Y. Marunaka, “A role of PI3 kinase in insulin-induced enhancement of cAMP-stimulated Cl- secretion in renal epithelia A6 cells,” Journal of Physiological Sciences, vol. 63, p. S197, 2013. View at Google Scholar
  28. L. R. Carraro-Lacroix, L. M. A. Lessa, C. N. A. Bezerra et al., “Role of CFTR and ClC-5 in modulating vacuolar H+-ATPase activity in kidney proximal tubule,” Cellular Physiology and Biochemistry, vol. 26, no. 4-5, pp. 563–576, 2010. View at Publisher · View at Google Scholar · View at Scopus
  29. R. R. Hodges and D. A. Dartt, “Tear film mucins: front line defenders of the ocular surface, comparison with airway and gastrointestinal tract mucins,” Experimental Eye Research, vol. 117, pp. 62–78, 2013. View at Google Scholar
  30. V. Singh, J. Yang, T. E. Chen et al., “Translating molecular physiology of intestinal transport into pharmacologic treatment of diarrhea: stimulation of Na+ absorption,” Clinical Gastroenterology and Hepatology, vol. 12, no. 1, pp. 27–31, 2014. View at Google Scholar
  31. L. Al-Nakkash, “Genistein stimulates jejunal chloride secretion via sex-dependent, estrogen receptor or adenylate cyclase mechanisms,” Cellular Physiology and Biochemistry, vol. 30, no. 1, pp. 137–150, 2012. View at Google Scholar
  32. L. Al-Nakkash, L. Batia, M. Bhakta et al., “Stimulation of murine intestinal secretion by daily genistein injections: gender-dependent differences,” Cellular Physiology and Biochemistry, vol. 28, no. 2, pp. 239–250, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. D. Collins, S. Kopic, J. P. Geibel et al., “The flavonone naringenin inhibits chloride secretion in isolated colonic epithelia,” European Journal of Pharmacology, vol. 668, no. 1-2, pp. 271–277, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. H. Fischer and B. Illek, “Activation of the CFTR Cl- channel by trimethoxyflavone in vitro and in vivo,” Cellular Physiology and Biochemistry, vol. 22, no. 5-6, pp. 685–692, 2008. View at Publisher · View at Google Scholar · View at Scopus
  35. S. Zhang, N. Smith, D. Schuster et al., “Quercetin increases cystic fibrosis transmembrane conductance regulator-mediated chloride transport and ciliary beat frequency: therapeutic implications for chronic rhinosinusitis,” American Journal of Rhinology and Allergy, vol. 25, no. 5, pp. 307–312, 2011. View at Publisher · View at Google Scholar · View at Scopus
  36. Z.-H. Yang, H.-J. Yu, A. Pan et al., “Cellular mechanisms underlying the laxative effect of flavonol Naringenin on rat constipation model,” PLoS ONE, vol. 3, no. 10, Article ID e3348, 2008. View at Publisher · View at Google Scholar · View at Scopus
  37. M. Sousa, J. Ousingsawat, R. Seitz et al., “An extract from the medicinal plant Phyllanthus acidus and its isolated compounds induce airway chloride secretion: a potential treatment for cystic fibrosis,” Molecular Pharmacology, vol. 71, no. 1, pp. 366–376, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. C. Muanprasat, L. Sirianant, S. Soodvilai, R. Chokchaisiri, A. Suksamrarn, and V. Chatsudthipong, “Novel action of the chalcone isoliquiritigenin as a cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor: potential therapy for cholera and polycystic kidney disease,” Journal of Pharmacological Sciences, vol. 118, no. 1, pp. 82–91, 2012. View at Publisher · View at Google Scholar · View at Scopus
  39. M. Schuier, H. Sies, B. Illek, and H. Fischer, “Cocoa-related flavonoids inhibit CFTR-mediated chloride transport across T84 human colon epithelia,” Journal of Nutrition, vol. 135, no. 10, pp. 2320–2325, 2005. View at Google Scholar · View at Scopus
  40. L. Mezesova, M. Bartekova, V. Javorkova, J. Vlkovicova, A. Breier, and N. Vrbjar, “Effect of quercetin on kinetic properties of renal na,k-atpase in normotensive and hypertensive rats,” Journal of Physiology and Pharmacology, vol. 61, no. 5, pp. 593–598, 2010. View at Google Scholar · View at Scopus
  41. D. Blaskovic, P. Zizkova, F. Drzik, J. Viskupicova, M. Veverka, and L. Horakova, “Modulation of rabbit muscle sarcoplasmic reticulum Ca2+-ATPase activity by novel quercetin derivatives,” Interdisciplinary Toxicology, vol. 6, no. 1, pp. 3–8, 2013. View at Google Scholar
  42. O. A. Ogunbayo and F. Michelangeli, “Related flavonoids cause cooperative inhibition of the sarcoplasmic reticulum Ca2+ ATPase by multimode mechanisms,” FEBS Journal, vol. 281, no. 3, pp. 766–777, 2014. View at Google Scholar
  43. R. Flamini, F. Mattivi, M. de Rosso, P. Arapitsas, and L. Bavaresco, “Advanced knowledge of three important classes of grape phenolics: anthocyanins, stilbenes and flavonols,” International Journal of Molecular Sciences, vol. 14, no. 10, pp. 19651–[19669, 2013. View at Google Scholar
  44. K. P. Vandock, M. J. Mitchell, and C. F. Fioravanti, “Effects of plant flavonoids on manduca sexta (tobacco hornworm) fifth larval instar midgut and fat body mitochondrial transhydrogenase,” Archives of Insect Biochemistry and Physiology, vol. 80, no. 1, pp. 15–25, 2012. View at Publisher · View at Google Scholar · View at Scopus
  45. Y.-H. Kim, D.-H. Lee, J.-H. Jeong, Z. S. Guo, and Y. J. Lee, “Quercetin augments TRAIL-induced apoptotic death: involvement of the ERK signal transduction pathway,” Biochemical Pharmacology, vol. 75, no. 10, pp. 1946–1958, 2008. View at Publisher · View at Google Scholar · View at Scopus
  46. C. Mu, P. Jia, Z. Yan, X. Liu, X. Li, and H. Liu, “Quercetin induces cell cycle G1 arrest through elevating Cdk inhibitors p21 and p27 in human hepatoma cell line (HepG2),” Methods and Findings in Experimental and Clinical Pharmacology, vol. 29, no. 3, pp. 179–183, 2007. View at Publisher · View at Google Scholar · View at Scopus
  47. D. F. Farias, T. M. Souza, M. P. Viana et al., “Antibacterial, antioxidant, and anticholinesterase activities of plant seed extracts from Brazilian semiarid region,” BioMed Research International, vol. 2013, Article ID 510736, 9 pages, 2013. View at Publisher · View at Google Scholar
  48. P. Strobel, C. Allard, T. Perez-Acle, R. Calderon, R. Aldunate, and F. Leighton, “Myricetin, quercetin and catechin-gallate inhibit glucose uptake in isolated rat adipocytes,” Biochemical Journal, vol. 386, part 3, pp. 471–478, 2005. View at Publisher · View at Google Scholar · View at Scopus
  49. W. Aoi, N. Niisato, H. Miyazaki, and Y. Marunaka, “Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat,” Biochemical and Biophysical Research Communications, vol. 315, no. 4, pp. 892–896, 2004. View at Publisher · View at Google Scholar · View at Scopus
  50. M. I. Kazeem, J. O. Adamson, and I. A. Ogunwande, “Modes of inhibition of alpha-amylase and alpha-glucosidase by aqueous extract of Morinda lucida Benth leaf,” BioMed Research International, vol. 2013, Article ID 527570, 6 pages, 2013. View at Publisher · View at Google Scholar
  51. L. Wang, S. Q. Lin, Y. L. He, G. Liu, and Z. Y. Wang, “Protective effects of quercetin on cadmium-induced cytotoxicity in primary cultures of rat proximal tubular cells,” Biomedical and Environmental Sciences, vol. 26, no. 4, pp. 258–267, 2013. View at Google Scholar