Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6

<table>Sirt6 overexpression does not affect the expression of other Sirts. ECs were infected with adenovirus carrying Sirt6 gene (Ad-Sirt6) or empty vector (control, Ad-Con) for 2 days. The levels of other Sirts were determined by quantitative PCR and normalized to control.</table>

BioMed Research International

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Figure 5

Figure 5: Oxidative Stress Induces Endothelial Cell Senescence via Downregulation of Sirt6 