Reduction-Triggered Breakable Micelles of Amphiphilic Polyamide Amine-g-Polyethylene Glycol for Methotrexate Delivery

Table 1

Synthesis of amphiphilic polyamide amine-g-polyethylene glycol graft copolymers.

Entry	PAA		PAA-g-MPEG
	BAC/phenylethylamine; /ethanolamine		Graft; efficiency*
	Feed ratio	Measured ratio*
PAA(8:2)-PEG2000	9/8/2	9/8/2	93%
PAA(7:3)-PEG2000	9/7/3	9/7/3	84%
PAA(6:4)-PEG2000	9/6/4	9/6/4	71%
PAA(8:2)-PEG5000	9/8/2	9/8/2	79%
PAA(7:3)-PEG5000	9/7/3	9/7/3	67%
PAA(6:4)-PEG5000	9/6/4	9/6/4	58%

∗Calculated from peak areas of respective protons in ¹H NMR.