Inflammation Induced by Perfluorocarbon Liquid: Intra- and Postoperative Use

Table 3

PFCLs used as medium-term tamponade [33–38].

PFCL	Pathology	Tamponade time	Follow-up	Study	Results	Inflammation
C8F18	Inferior RD with or without PVR	17.4 days to; SF6	32 months	Case series; 𝑁=157; (Sigler 2013)	Primary reattachment rate after PFCL and tamponade removal 87.5%; Mean VA change in logMAR 0.15±0.87; PFCL in anterior chamber 22%; IOP high 34%; PFCL in anterior chamber 21%; Inflammation 27%; Cataract surgery16%; Glaucoma surgery 6%	Granulomatous inflammatory precipitates 27%
C8F18	Recurrent inferior RD with PVR	18.3 days to fluid	30.71 months	Case series; 𝑁=44; (Sigler 2013)	Primary reattachment rate after PFCL removal 86%; Mean VA change in logMAR 0.08±0.13; PFCL in anterior chamber 22%; IOP high 36%; PFCL in anterior chamber 32%; Inflammation 32%; Cataract surgery 42%; Glaucoma surgery 5%	Granulomatous inflammatory precipitates 32%
C8F18	RD with GRT without PVR	16.4 days to C3F8	53.9 weeks	Case series; 𝑁=16; (Rofail and lee 2005) [36]	Primary reattachment rate after PFCL and tamponade removal 100%; Redetachment 6,3%; VA improvement 68.8%; VA stable 12.5%; Cataract 54.5%; ERM 25%; Hypotony 18.6%; Inflammation 6%	Inflammatory reaction in AC after PFCL removal with fibrin over the pupil
C8F18	Inferior RD	19 days to air	29.7 months	Case series; 𝑁=181; (Sigler 2013)	Primary reattachment rate after PFCL removal 88%; Final VA 0.81±0.67; Inflammation 28%	Foreign-body response 28%
C8F18	Inferior RD with or without GRT	11 days		Case series; 𝑁=39; (Rush et al. 2012) [37]	Primary reattachment rate 92.4%; Severe inflammation 20.6%; IOP > 21 35.9%; Cataract surgery 84%	Mild inflammation 79%; Severe inflammation 21%; Pupillary membrane 9%
C10F18	RD with GRT	2 weeks to SF6		Single case; (Singh et al 2001) [38]	Typical inflammatory reaction 7 days after PFCL removal	Macrophages and epithelial cells