Human Umbilical Cord Mesenchymal Stem Cells Infected with Adenovirus Expressing HGF Promote Regeneration of Damaged Neuron Cells in a Parkinson’s Disease Model
Figure 3
(a) Cell viability of SH-SY5Y underwent various treatments. Control: no-treatment; model: treated with MMP+ at 1000 M; CM-MSC: treated with MMP+ at 1000 M and then incubated with cultural supernatant of hUC-MSC; CM-HGF: treated with MMP+ at 1000 M and then incubated with cultural supernatant of hUC-MSC infected with Ad-HGF. Viability in PD model cells was significantly decreased compared to control (). After being treated with either CM-HGF or CM-MSC for 48 h, cell viability was significantly increased compared to the PD model () and compared with the normal control group (). Significant difference between CM-MSC and CM-HGF treatment was seen after 48 h treatment (). (b) Microscopic images of cells with various treatments. The SH-SY5Y cells under each treatment were stained with crystal violet and observed under an inverted microscope.
