Synthesis and Preclinical Characterization of [¹⁸F]FPBZA: A Novel PET Probe for Melanoma

Figure 6

(a) Representative coronal (top) and transaxial (bottom) [¹⁸F]FPBZA microPET images of C57BL/6 mice bearing B16F0 melanoma lung metastases and normal mice. Static microPET images were obtained at 0.5, 1, and 2 h after bolus injection of 1.85–3.7 MBq of [¹⁸F]FPBZA via the tail vein. Arrows indicated tumors. (b) Quantification of the uptake of [¹⁸F]FPBZA by B16F0 melanoma lung metastases, normal lungs, liver, and muscle derived from microPET images after intravenous injection. SUVs were expressed in  %ID/g ± SD ().

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