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BioMed Research International
Volume 2014 (2014), Article ID 915797, 8 pages
Research Article

In Vitro Larvicidal and Antioxidant Activity of Dihydrophenanthroline-3-carbonitriles

1Chemistry Research Laboratory, Organic Chemistry Division, School of Advanced Sciences, VIT University, Vellore, Tamil Nadu 632 014, India
2Unit of Nanotechnology and Bioactive Natural Products, Post Graduate and Research, Department of Zoology, C. Abdul Hakeem College, Melvisharam, Vellore District, Tamil Nadu 632 509, India

Received 23 February 2014; Accepted 1 April 2014; Published 24 April 2014

Academic Editor: Kota V. Ramana

Copyright © 2014 A. Bharathi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Many naturally occurring and synthetic compounds containing dihydrocyanopyridine and cyanopyran moiety show pharmacological properties. The aim of this study is to investigate the larvicidal and antioxidant potential of dihydrophenanthroline-3-carbonitrile derivatives 4a–f. A novel series of 2-amino-10-chloro-4,12-diphenyl-1,4,5,6-tetrahydrobenzo[j][1,7]phenanthroline-3-carbonitrile derivatives were synthesized by reacting different substituted acridine chalcones through Michel addition. The compounds were synthesized in excellent yields and the structures were corroborated on the basis of FT-IR, 1H NMR, 13C NMR, and ESI Mass analysis data. All the synthesized compounds were evaluated for larvicidal activity against Aedes aegypti and Culex quinquefasciatus larvae. Furthermore, the antioxidant activity was studied by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay method. From the antioxidant assay, the compound 4c was reported with profound antioxidant potential.