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BioMed Research International
Volume 2014, Article ID 917150, 8 pages
Review Article

Role of CT Perfusion in Monitoring and Prediction of Response to Therapy of Head and Neck Squamous Cell Carcinoma

1Division of Radiology, European Institute of Oncology, University of Milan, Via Ripamonti 435, 20141 Milan, Italy
2University of Milan, Via Festa del Perdono 7, 20122 Milan, Italy
3Division of Medical Oncology, European Institute of Oncology, Via Ripamonti 435, 20141 Milan, Italy

Received 20 May 2014; Accepted 5 July 2014; Published 21 July 2014

Academic Editor: Mazzei Maria Antonietta

Copyright © 2014 Lorenzo Preda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This review aims to summarize the technique and clinical applications of CT perfusion (CTp) of head and neck cancer. The most common pathologic type (90%) of head and neck cancer is squamous cell carcinoma (HNSCC): its diagnostic workup relies on CT and MRI, as they provide an accurate staging for the disease by determining tumour volume, assessing its extension, and detecting of lymph node metastases. Compared with conventional CT and MRI, CTp allows for obtaining measures of tumour vascular physiology and functional behaviour, and it has been demonstrated to be a feasible and useful tool in predicting local outcomes in patients undergoing radiation therapy and chemotherapy and may help monitor both treatments.