BioMed Research International

Review Article

Role of CT Perfusion in Monitoring and Prediction of Response to Therapy of Head and Neck Squamous Cell Carcinoma

Table 2

Results for the prediction of response to radiotherapy and chemotherapy based on the pretreatment tumour volume and the perfusion-associated parameters.


Author	Cancer	Number of patients	Predictive parameters	value	Type of study

Hermans et al. [12]	Primary HNSCC	105	Median perfusion value	0.01	Prospective

Zima et al. [13]	SCCA of the upper aerodigestive tract	17	BF	<0.03	Prospective
Zima et al. [13]	SCCA of the upper aerodigestive tract		BV	<0.004	Prospective

Bisdas et al. [14]	Advanced oropharynx SCCA	19	BF, BV, PS, MTT	<0.001	Prospective

Petralia et al. [9]	SCCA of the upper aerodigestive tract	25	BV	0.015

Bisdas et al. [15]	Primary SCCA of oral cavity, oropharynx, hypopharynx	21	BF, BV, MTT, PS	<0.004	Prospective
Bisdas et al. [15]	Primary SCCA of oral cavity, oropharynx, hypopharynx		BF_max, BV_max	<0.001	Prospective

Bisdas et al. [16]	SCCA of the upper aerodigestive tract	84	BF, PS	<0.000	Prospective
Bisdas et al. [16]	SCCA of the upper aerodigestive tract		BF-BV mismatch	0.01	Prospective

Notes: SCCA: squamous cell carcinoma; HNSCC: head and neck squamous cell carcinoma; BF: blood flow; BV: blood volume; PS: permeability surface area product; MTT: mean transit time; and CP: capillary permeability surface area product.