The E3 Ligase CHIP: Insights into Its Structure and Regulation

Figure 5

Schematic representation of regulatory protein interactions between CHIP and various reported proteins. (a) Competition with substrate binding, (b) competition with chaperone binding, (c) conformational modification of CHIP, (d) disruption of CHIP and E2 interaction, (e) facilitation of chaperone binding, and (f) facilitation of interaction with E2. See text for details.