Ameliorative Effect of Saffron Aqueous Extract on Hyperglycemia, Hyperlipidemia, and Oxidative Stress on Diabetic Encephalopathy in Streptozotocin Induced Experimental Diabetes Mellitus

Table 1

Effect of saffron extract on body weight in STZ-treated diabetic rats. Control (C), untreated diabetic rats (D), saffron extract (20 mg/kg/day)—treated diabetic rats (L-saf), saffron extract (40 mg/kg/day)—treated diabetic rats (M-saf), and saffron extract (80 mg/kg/day)—treated diabetic rats (H-saf) during 4 weeks of study.

Days	0	7	14	21	28
C
Body weight (g)	199 ± 10	240 ± 12	257 ± 14	276 ± 16	301 ± 18
D
Body weight (g)	215 ± 13	210 ± 11***	201 ± 12***	192 ± 10***	183 ± 11***
L-saf
Body weight (g)	188 ± 12	184 ± 7**	180 ± 9**	187 ± 13**	194 ± 15**
M-saf
Body weight (g)	208 ± 11	211 ± 12*	220 ± 14*	226 ± 13^**,+	231 ± 12^**,+
H-saf
Body weight (g)	199 ± 9	203 ± 10	216 ± 12	228 ± 18^+	239 ± 14^++

Each measurement was done at least in triplicate and the values are the means 00B1 SEM for eight rats in each group.
Significantly different from normal control (Group C) rats (^∗𝑃<0.05, ^∗∗𝑃<0.01, ^∗∗∗𝑃<0.001).
Significantly different from STZ-treated (Group D) rats (⁺𝑃<0.05, ⁺⁺𝑃<0.01).