Topography Prediction of Helical Transmembrane Proteins by a New Modification of the Sliding Window Method

Table 1

Hydrophobicity scales 𝐻_𝑁(𝑖).

𝑖	Code	Abbreviation	Name	𝐻1(𝑖), [14]	𝐻2(𝑖), [19]	𝐻3(𝑖), [19]	𝐻4(𝑖), [17, 19]	𝐻5(𝑖), [18]	𝐻6(𝑖), [16]	𝐻7(𝑖) [20]
1	A	Ala	Alanine	1.8	0	0	0.74	0.62	1.60	−0.17
2	C	Cys	Cysteine	2.5	1	1	0.91	0.29	2.00	0.24
3	D	Asp	Aspartic acid	−3.5	0	−1	0.62	−0.90	−9.20	−1.23
4	E	Glu	Glutamic acid	−3.5	0	−1	0.62	−0.74	−8.20	−2.02
5	F	Phe	Phenylalanine	2.8	1	1	0.88	1.19	3.70	1.13
6	G	Gly	Glycine	−0.4	0	−1	0.72	0.48	1.00	−0.01
7	H	His	Histidine	−3.2	0	0	0.78	−0.40	−3.00	−0.96
8	I	Ile	Isoleucine	4.5	1	1	0.88	1.38	3.10	0.31
9	K	Lys	Lysine	−3.9	0	−1	0.52	−1.50	−8.80	−0.99
10	L	Leu	Leucine	3.8	1	1	0.85	1.06	2.80	0.56
11	M	Met	Methionine	1.9	1	1	0.85	0.64	3.40	0.23
12	N	Asp	Asparagine	−3.5	0	−1	0.63	−0.78	−4.80	−1.23
13	P	Pro	Proline	−1.6	0	−1	0.64	0.12	−0.20	−0.45
14	Q	Gln	Glutamine	−3.5	0	−1	0.62	−0.85	−4.10	−0.58
15	R	Arg	Arginine	−4.5	0	−1	0.64	−2.53	−12.3	−0.81
16	S	Ser	Serine	−0.8	0	−1	0.66	−0.18	0.60	−0.13
17	T	Thr	Threonine	−0.7	0	−1	0.70	−0.05	1.20	−0.14
18	V	Val	Valine	4.2	1	1	0.86	1.08	2.60	−0.07
19	W	Trp	Tryptophan	−0.9	1	1	0.85	0.81	1.90	1.85
20	Y	Tyr	Tyrosine	−1.3	0	0	0.76	0.26	−0.70	0.94