Intraportal Infusion of Ghrelin Could Inhibit Glucose-Stimulated GLP-1 Secretion by Enteric Neural Net in Wistar Rat
Figure 2
Plasma concentrations of glucose (a), insulin (b), and GLP-1 (c) during ghrelin infusion in the OGTT after hepatic vagotomy. After a 30 min rest after hepatic vagotomy or sham operation, ghrelin (1 ng/kg/mL) was infused into the portal vein (i.p.) from 0 to 60 min at a rate of 1 mL/h using a micropump. A 20% glucose solution (1 g/kg) was administered through stomach catheter orally. Data are represented as mean ± SE. Open squares, saline i.p. with sham operation group (); closed squares, ghrelin i.p. with sham operation group; open triangles, saline i.p. with hepatic vagotomy group (); and closed triangles, ghrelin i.p. with hepatic vagotomy group (). versus saline i.p. with sham operation group; versus saline i.p. with sham operation group.
