FOXO Transcription Factors: Their Clinical Significance and Regulation
Figure 3
Mechanisms of FOXO1 in normal wound healing. The normal wound healing process is initiated by the integration of multiple intercellular signals (cytokines and chemokines) released by keratinocytes and other cells. FOXO1 is required for keratinocyte transition to a wound-healing phenotype. FOXO1 in vivo is needed for keratinocyte expression of transforming growth factor-1 (TGF-1) expression, induction of TGF1 downstream targets (integrin-3 and -6 and MMP-3 and -9), and migration. Migration (bold arrow) is particularly important in wound healing. FOXO1 is also needed to protect keratinocytes from oxidative stress, which contributes to keratinocyte migration and survival during normal wound healing. This is adapted from [19].
