Prevention and Restoration of Hearing Loss Associated with the Use of Cisplatin

Table 1

Mechanisms of ototoxicity.

Cellular mechanisms of ototoxicity	Molecular mechanisms of ototoxicity
(i) Damage to outer hair cells; (ii) Damage to supporting cells; (iii) Damage to marginal cells of stria vascularis; (iv) Damage to the spiral ligament; (v) Damage to spiral ganglion cells	(i) Creation of reactive oxygen species; (ii) Depletion of antioxidant glutathione and its regenerating enzymes; (iii) Increased rate of lipid peroxidation; (iv) Oxidative modifications of proteins; (v) Nucleic acids damage by caspase system activation; (vi) S-Nitrosylation of cochlear proteins