Prevention and Restoration of Hearing Loss Associated with the Use of Cisplatin
Table 1
Mechanisms of ototoxicity.
Cellular mechanisms of ototoxicity
Molecular mechanisms of ototoxicity
(i) Damage to outer hair cells (ii) Damage to supporting cells (iii) Damage to marginal cells of stria vascularis (iv) Damage to the spiral ligament (v) Damage to spiral ganglion cells
(i) Creation of reactive oxygen species (ii) Depletion of antioxidant glutathione and its regenerating enzymes (iii) Increased rate of lipid peroxidation (iv) Oxidative modifications of proteins (v) Nucleic acids damage by caspase system activation (vi) S-Nitrosylation of cochlear proteins