The (G>A) rs11573191 Polymorphism of PLA2G5 Gene Is Associated with Premature Coronary Artery Disease in the Mexican Mestizo Population: The Genetics of Atherosclerotic Disease Mexican Study
Table 2
Comparison of biochemical parameters in individuals with premature coronary artery disease and controls.
Controls
Premature CAD
( = 749)
( = 707)
Total cholesterol (mg/dL)
19338 ± 36.46
169.31 ± 48.18
<0.0001
TC > 200 mg/dL (%)
40.0
20.7
<0.0001
HDL-C (mg/dL)
46.61 ± 13.69
39.90 ± 10.82
<0.0001
Hipo-a-lipoproteinemia (%)
51.2
57.5
0.009
LDL-C (mg/dL)
118.69 ± 32.37
97.22 ± 40.25
<0.0001
Triglycerides (mg/dL)
170.47 ± 113.01
193.72 ± 127.26
<0.0001
Hypertriglyceridemia (%)
46.9
59.8
<0.0001
ApoAI (mg/dL)
139.50 ± 43.68
119.32 ± 26.74
<0.0001
ApoB (mg/dL)
91.32 ± 28.85
82.71 ± 31.01
<0.0001
Statin and/or fibrate treatment (%)
4.2
15.4
<0.0001
Type 2 diabetes mellitus (%)
7.6
35.3
<0.0001
Glucose (mg/dL)
100.75 ± 35.75
112.33 ± 44.31
0.001
HOMA-IR
5.29 ± 8.38
6.73 ± 6.00
<0.0001
Insulin (U/mL)
20.32 ± 13.82
24.23 ± 17.26
<0.0001
Metabolic syndrome (%)
46.3
46.1
0.488
Uric acid (mg/dL)
5.47 ± 1.78
6.07 ± 2.06
<0.0001
Creatinine (mg/dL)
0.84 ± 0.25
0.92 ± 0.31
<0.0001
Alanine transaminase (IU/L)
27.75 ± 12.43
28.07 ± 11.49
0.619
Aspartate transaminase (IU/L)
26.84 ± 11.34
27.97 ± 17.77
0.222
Alkaline phosphatase (IU/L)
83.07 ± 28.36
78.99 ± 25.97
0.004
Gamma-glutamyl transpeptidase (IU/L)
35.91 ± 32.83
44.36 ± 44.63
<0.0001
Data are expressed as means ± SD; log-transformed values were used for statistical analysis. values were estimated using ANOVA for continuous variables and Pearson’s Chi-square test for categorical values. CAD: coronary artery disease.
