Isocudraxanthone K Induces Growth Inhibition and Apoptosis in Oral Cancer Cells via Hypoxia Inducible Factor-1α
Figure 6
Effects of isocudraxanthone K on expression of HIF-1α and VEGF in HN4 (a) and HN12 (b) cells. Cells were cultured without or with various concentrations of IK for 2 days. mRNA and protein levels were assessed by RT-PCR and Western blot analysis, respectively. The results are representative of three independent experiments. The histogram shows the quantification of gene expression by densitometry and is presented as fold increases compared to nonstimulated control cells. Statistically significant difference, compared with control, .
