The Role of Genetic Factors and Kidney and Liver Function in Glycemic Control in Type 2 Diabetes Patients on Long-Term Metformin and Sulphonylurea Cotreatment
Table 1
Patients’ clinical characteristics.
All patients ()
Not treated with statins ()
Treated with statins ()
Gender: male/female [number (%)]
78 (57.8)/57 (42.2)
27 (57.4)/20 (42.6)
51 (58.0)/37 (42.0)
1.000a
Age (years) [median (25%–75%)]
64 (59–70)
64 (57–70)
65 (60–70)
0.310b
BMI (kg/m2) [median (25%–75%)]
29 (28–34)
29 (28–32)
30 (28–34)
0.545b
BMI > 30 [number (%)]
55 (40.7)
16 (34.0)
39 (44.3)
0.274a
BMI > 35 [number (%)]
23 (17.0)
6 (12.8)
17 (19.3)
0.354a
Duration of diabetes (years) [median (25%–75%)]
11 (6–16)
11 (5–16)
10 (7–15)
0.967b
Duration of metformin treatment (years) [median (25%–75%)]
5 (4–8)
5 (3–8)
6 (4–8)
0.487b
Metformin dose (mg) [median (25%–75%)]
2550 (2000–2550)
2550 (1700–2550)
2550 (2000–2550)
0.202b
HbA1c (%) [median (25%–75%)]d
6.9 (6.4–7.6)
6.7 (6.2–7.7)
6.9 (6.5–7.6)
0.424b
Glucose (mmol/L) [median (25%–75%)]e
7.5 (6.7–8.8)
7.6 (6.7–8.8)
7.5 (6.7–8.8)
0.854b
Patients with hypoglycemia [number (%)]
28 (20.7)
7 (14.9)
21 (23.9)
0.269a
Serum creatinine (μmol/L) [median (25%–75%)]
75 (64–87)
83 (64–91)
73 (63.3–83)
0.115b
eGF (mL/min) [median (25%–75%)]
82 (68–90)
78 (66–90)
84 (68.3–90)
0.473b
Urea (mmol/L) [median (25%–75%)]
5.4 (4.4–6.6)
5.3 (4.4–6.9)
5.4 (4.3–6.4)
0.872b
Albuminuria (mg/L) [median (25%–75%)]
9 (3.7–35.7)
7.1 (3.7–41.4)
9.5 (3.7–35.6)
0.642b
AST (μkat/L) [median (25%–75%)]c
0.41 (0.35–0.50)
0.39 (0.35–0.51)
0.41 (0.35–0.50)
0.785b
ALT (μkat/L) [median (25%–75%)]c
0.45 (0.36–0.62)
0.435 (0.36–0.54)
0.48 (0.35–0.68)
0.246b
GGT (μkat/L) [median (25%–75%)]
0.42 (0.31–0.77)
0.42 (0.32–0.90)
0.42 (0.31–0.76)
0.621b
Total cholesterol (mmol/L) [median (25%–75%)]
4.3 (3.8–5.2)
4.8 (4–5.6)
4.1 (3.8–4.9)
LDL cholesterol (mmol/L) [median (25%–75%)]
2.4 (1.9–3.3)
3 (2.1–3.6)
2.3 (1.9–2.9)
HDL cholesterol (mmol/L) [median (25%–75%)]c
1.2 (1.0–1.4)
1.3 (1–1.5)
1.2 (1–1.4)
0.342b
TAG (mmol/L) [median (25%–75%)]
1.6 (1.3–2.4)
1.5 (1.1–2)
1.8 (1.3–2.7)
Calculated using Fisher exact test; bcalculated using Mann-Whitney test; cdata missing for 1 patient; ddata missing for 3 patients; edata for 88 patients (28 not treated with statins and 60 treated with statins).
