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BioMed Research International
Volume 2014 (2014), Article ID 934732, 6 pages
http://dx.doi.org/10.1155/2014/934732
Research Article

Hepatoprotective Effect of Superfine Particles of Herbal Medicine against CCl4-Induced Acute Liver Damage in Rats

1Research Center of TCM Processing Technology, Zhejiang Chinese Medical University, Hangzhou 310053, China
2Zhejiang Cancer Hospital, Hangzhou, China
3The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China
4Department of Chinese Materia Medica, College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China
5Faculty of Medicine, University of New South Wales, Sydney, NSW 2031, Australia

Received 3 March 2014; Revised 7 May 2014; Accepted 12 May 2014; Published 9 June 2014

Academic Editor: Yi Zhang

Copyright © 2014 Gang Cao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aimed to examine the hepatoprotective effects of the superfine particles of Radix Tetrastigma (SPRT) against CCl4-induced acute liver damage in rats. Animals were treated with SPRT (0.3, 0.6, and 1.2 g/kg) and showed remarkable hepatoprotection against CCl4-induced hepatotoxicity. CCl4 altered various biochemical parameters in rat liver, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), malondialdehyde (MDA), superoxide dismutase (SOD), histopathological changes, and Bax and caspase-3 expressions. SPRT significantly prevented increases in ALT and AST levels, reduced MDA level, decreased Bax and caspase-3 protein expression, enhanced SOD activity, and provided significant amelioration in the histopathological lesions. These findings suggested that SPRT has significant protective effect against acute hepatotoxicity induced by CCl4 in rats.