The K–Cl Cotransporter KCC3 as an Independent Prognostic Factor in Human Esophageal Squamous Cell Carcinoma

Table 2

Relationships between the clinicopathological features of esophageal cancer and expression of KCC3 in the invasive front of the tumor.

Variable	Invasive front		𝑃 value
	Negative	Positive
	(𝑛=22)	(𝑛=48)
Age
<60 years	6	16	0.783
≥60 years	16	32
Gender
Male	21	38	0.154
Female	1	10
Location of the primary tumor
Ut-Mt	12	35	0.172
Lt-Ae	10	13
Histological type
Well/moderately differentiated SCC	15	34	1.000
Poorly differentiated SCC	7	14
Tumor size
<50 mm	14	35	0.575
≥50 mm	8	13
Lymphatic invasion
Negative	10	23	1.000
Positive	12	25
Venous invasion
Negative	13	27	1.000
Positive	9	21
pT
pT1	8	25	0.3035
pT2-3	14	23
pN
pN0	8	25	0.3035
pN1-3	14	23
MT
Low	20	15	<0.0001*
High	2	33
CN
Low	19	17	<0.0001*
High	3	31
CN/MT
CN ≤ MT	14	17	0.0385*
CN > MT	8	31

Ut: upper thoracic esophagus; Mt: middle thoracic esophagus; Lt: lower thoracic esophagus; Ae: abdominal esophagus; SCC: squamous cell carcinoma; pT: pathological T stage; pN: pathological N stage; MT: main tumor; CN: cancer nest.
^∗𝑃<0.05: Fisher’s exact test.