ATP Release through Lysosomal Exocytosis from Peripheral Nerves: The Effect of Lysosomal Exocytosis on Peripheral Nerve Degeneration and Regeneration after Nerve Injury

Figure 1

Model of lysosomal exocytosis events in Schwann cells during Wallerian degeneration. After peripheral nerve injury, secretory lysosomal activation is increased, which triggers lysosomal exocytosis during Wallerian degeneration. Through lysosomal exocytosis, Schwann cells release ATP into the extracellular space. The released ATP transmits to neighboring Schwann cells and promotes lysosomal activation and subsequent lysosomal exocytosis.