Multiple Analytical Approaches Demonstrate a Complex Relationship of Genetic and Nongenetic Factors with Cisplatin- and Carboplatin-Induced Nephrotoxicity in Lung Cancer Patients

Table 2

Nephrotoxicity risk score.

Parameter	coefficient	OR	95% CI	Score
Nongenetic factors
Baseline Scr ≤1 mg/dL	2.303	10.0	1.57~62.9	5
Cisplatin	1.790	5.99	1.53~23.5	4
Coadministration of vinorelbine	1.369	3.93	0.86~18.1	3
Smoking	0.528	1.69	0.41~7.05	2
Number of cycles >4	0.098	1.10	0.47~4.93	1
Genetic factors
TP53 wild-type	0.989	2.70	0.91~9.14	2
ERCC1 C118T wild-type	0.990	2.70	0.90~8.35	2

OR: odds ratio; CI: confidence interval; Src: serum creatine.