Ceftriaxone, a Beta-Lactam Antibiotic, Modulates Apoptosis Pathways and Oxidative Stress in a Rat Model of Neuropathic Pain

Table 1

The effect of intraperitoneal ceftriaxone (200 mg/kg) on the levels of malondialdehyde (MDA) and glutathione (GSH) in the lumbar spinal cord of 3- and 7-day CCI rats. Animals were treated with ceftriaxone for 7 days and administration started when CCI was induced. Data are presented as mean ± SEM (𝑛=3). One-way ANOVA followed by Tukey’s post hoc test was used for multiple comparisons. ^##𝑃<0.01, ^#𝑃<0.05 difference between CCI-NS and sham/naive animals. *𝑃<0.05 CCI-Cef group versus NS-CCI group (control).

	Control group (normal saline CCI rats)	Sham group	Naive group (intact rats with daily 200 mg/kg ceftriaxone)	Treated group (CCI rats with daily 200 mg/kg ceftriaxone)
MDA (nmol/mg protein)
Day 3	12.9 ± 2.5^##	4.3 ± 0.23	4.7 ± 0.23	5.9 ± 1.2*
Day 7	10.7 ± 2.1^#	3 ± 0.16	3.1 ± 0.17	4.5 ± 1.2*
GSH (nmol/mg protein)
Day 3	37.7 ± 10.4	49 ± 11	41 ± 3.4	42.5 ± 3.8
Day 7	33.5 ± 4.6^##	55.2 ± 2.5	48.9 ± 2.3	40.6 ± 2.4*