Table of Contents Author Guidelines Submit a Manuscript
BioMed Research International
Volume 2014, Article ID 939738, 8 pages
http://dx.doi.org/10.1155/2014/939738
Research Article

Pleurodesis Induction in Rats by Copaiba (Copaifera multijuga Hayne) Oil

1Hospital Universitário Getúlio Vargas, Universidade Federal do Amazonas, Avenida Apurinã 4, Praça 14 de Janeiro, 69020-170 Manaus, AM, Brazil
2Hospital das Clínicas da Faculdade de Medicina, Instituto do Coração (InCor), Universidade de São Paulo, Avenida Dr. Enéas de Carvalho Aguiar, 44, Jardim Nossa Senhora Aparecida, 05403-900 São Paulo, SP, Brazil
3Departamento de Ciências Básicas da Saúde, Universidade Federal de Juiz de Fora, Câmpus Governador Valadares, Rua Israel Pinheiro, 2000, Bairro Universitário, 35010-177 Governador Valadares, MG, Brazil
4Instituto de Ciências Exatas, Universidade Federal do Amazonas, Avenida Rodrigo Otávio 6200, Coroado, 69.080-005 Manaus, AM, Brazil

Received 23 January 2014; Accepted 6 May 2014; Published 9 June 2014

Academic Editor: Kota V. Ramana

Copyright © 2014 Fernando Luiz Westphal et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aims to assess and compare copaiba oleoresin of Copaifera multijuga and 0.5% silver nitrate for the induction of pleurodesis in an experimental model. Ninety-six male Wistar rats were divided into three groups: control (0.9% saline solution), copaiba (copaiba oil), and silver nitrate (0.5% silver nitrate). The substances were injected into the right pleural cavity and the alterations were observed macroscopically and microscopically at 24, 48, 72, and 504 h. The value of macroscopic alterations grade and acute inflammatory reaction grade means was higher in the 24 h copaiba group in relation to silver nitrate. Fibrosis and neovascularization means in the visceral pleura were higher in 504 h copaiba group in relation to the silver nitrate group. The grade of the alveolar edema mean was higher in the silver nitrate group in relation to the copaiba group, in which this alteration was not observed. The presence of bronchopneumonia was higher in the 24 h silver nitrate group ( ) in relation to the copaiba group ( ). In conclusion, both groups promoted pleurodesis, with better results in copaiba group and the silver nitrate group presented greater aggression to the pulmonary parenchyma.