Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population

Table 2

Genotype, allele frequencies of GSTM1, GSTT1, GSTP1, GCLM, and GCLC polymorphisms of riverside persons living in the Amazonian region of the Tapajós River, Brazil.

Genotypes	Genotype frequencies		MAF^a			Reference MAF
						European	African
GSTM1	Present	Null	—	—	Null^c	Null^c
Deletion	0.66	0.34	—	—	0.13–0.54	0.47
GSTT1	Present	Null	—	—	Null^c	Null^c
Deletion	0.60	0.40	—	—	0.11–0.28	0.37
GSTP1 (Ile^105Val)	Ile/Ile	Ile/Val + Val/Val	Val (G)	HWE^b	Val (G)^d	Val (G)^g
rs1695	0.37	0.63	0.40	Yes	0.42	0.39
GCLM-588 (C/T)	CC	CT + TT	T	HWE	T^e	T^h
rs41303970	0.48	0.52	0.33	Yes	0.10	0.25
GCLC-128 (C/T)	CC	CT + TT	T	HWE	T^f	T^f
rs17883901	0.95	0.050	0.030	Yes	0.060	0.010

aMinor allele frequency.
bHWE: Hardy-Weinberg equilibrium. For the GSTM1 and GSTT1 deletions it was not possible to calculate HWE, because the methodology used does not distinguish between hetero- and homozygous genotypes.
cReference values from Mo et al. [32].
dReference values for ss1390210 from HapMap-CEU.
eReference values for ss230641266 from pilot_1_CEU_low_coverage_panel.
fReference values for ss66860389 from CEU_GENO_PANEL; YRI_GENO_PANEL.
gReference values for ss1390210 from HapMap-YRI.
hReference values for ss218528824 from pilot_1_YRI_low_coverage_panel.