Genetic Polymorphisms in Glutathione (GSH-) Related Genes Affect the Plasmatic Hg/Whole Blood Hg Partitioning and the Distribution between Inorganic and Methylmercury Levels in Plasma Collected from a Fish-Eating Population

Table 4

Total Hg in blood (THgB) and total Hg, methylmercury, and inorganic Hg in plasma (THgP, MeHgP, and IHgP, resp.) as well as the ratio THgP/THgB among the different genotypes.

Genotypes	THgB	THgP	MeHgP	IHgP	THgP/THgB
	Mean ± SD^d	Mean ± SD	Mean ± SD	Mean ± SD	Mean ± SD
GSTM1	37±21	10±4.4	4.4±2.5	5.9±2.4	0.33±0.16
Present	34±18	9.6±4.2	4.1±2.8	5.5±2.2	0.33±0.14
Null	44±24	12±4.7^∗	5.1±3.2	6.6±2.5^∗	0.34±0.18
GSTT1	37±21	10±4.4	4.4±2.9	5.9±2.4	0.33±0.16
Present	35±22	9.9±4.6	4.1±3.1	5.7±2.4	0.34±0.17
Null	40±19	11±4.1	5.0±2.7	6.0±2.3	0.31±0.13
GSTP1 ^a	38±21	10±4.0	4.3±2.5	5.8±2.3	0.32±0.16
Ile/Ile	40±22	11±3.7	4.5±2.3	6.1±2.4	0.33±0.15
Ile/Val + Val/Val	36±20	9.8±3.9	4.2±2.6	5.6±2.2	0.31±0.16
GCLM ^b	35±20	9.7±3.7	4.2±2.3	5.6±2.2	0.34±0.16
CC	33±21	10±4.1	4.5±2.4	5.7±2.6	0.38±0.16
CT + TT	36±19	9.4±3.2	3.9±2.3	5.5±1.7	0.30±0.13^∗
GCLC ^c	35±19	9.9±4.3	4.3±3.0	5.6±2.2	0.34±0.15
CC	34±20	9.7±4.1	4.1±2.9	5.5±2.1	0.33±0.16
CT + TT	42±12	15±6.2^∗	6.9±3.2^∗	8.1±3.1^∗	0.36±0.13

ars1695; brs41307970; crs17883901; darithmetic mean ± standard deviation (SD).
∗indicates significant difference between the wild genotypes and the polymorphic ones (Student’s 𝑡-test; 𝑃<0.050).