Effects and Tolerance of Silymarin (Milk Thistle) in Chronic Hepatitis C Virus Infection Patients: A Meta-Analysis of Randomized Controlled Trials

Table 1

Baseline characteristics of included trials.

Study	Silymarin dose	Drug administration	Interferon therapy, (%)	Intervention population	History of any milk thistle preparation use, (%)	Silymarin treatment duration	Country	Study type
Tanamly et al.; 2004 [10]	3 × 124.5 mg/day	Oral	NA	NA	NA	12 months	Egypt	RCT
Gordon et al.; 2006 [9]	600 mg or 1200 mg/day	Oral	10 (41.7)	NA	NA	12 weeks	Australia	RCT
Pár et al.; 2009 [8]	2 × 166 mg/day	Oral	32 (100)	Naïve	NA	3 months	Hungary	RCT
Fried et al.; 2012 [11]	3 × 420 mg or 700 mg/day	Oral	None	Failed to interferon therapy	68 (44.2)	24 weeks	USA	RCT
Mariño et al.; 2013 [12]	20 mg/kg/day	Intravenous	None	NVR = 11, naïve = 3	NA	28 days	Spain	RCT

NVR: nonvirologic response.