Muscle-Type Specific Autophosphorylation of CaMKII Isoforms after Paced Contractions

Figure 4

Phospho-Thr287-transient of βM CaMKII with 95% confidence intervals. Poisson distribution fitted to the set of output transients obtained by 4000 Latin hypercube-sampled input parameters sets from 75% to 125% of default values. The stimulation protocol with a pulse train of 100 pulses at 150 Hz was used and the model was set up for fast glycolytic muscle. The black line indicates the output transient using the default parameter set. The stippled blue lines indicate the upper and lower 2.5% confidence limit of the Poisson distribution.