Muscle-Type Specific Autophosphorylation of CaMKII Isoforms after Paced Contractions

Table 3

Rate constants.

Name	Value	Unit	Description	Reference
CaMax	25	[μM^−1]	Ca^2+ release rate	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
Power1	5	[---]	RyR kinetic parameter	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
tau1	0.609	[s]	RyR kinetic parameter	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
Power2	3	[---]	RyR kinetic parameter	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
tau2	0.774	[s]	RyR kinetic parameter	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
CaPump	20	[μM * ms^−1]	Maximum SERCA pumping	http://dare.ubvu.vu.nl/handle/1871/40249
KdPump	1	[μM]	Dissociation constant calcium binding to SERCA	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kAtp1	0.054	[μM^−1 * ms^−1]	On rate reaction Ca^2+-ATP	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kAtp2	120	[ms^−1]	Off rate reaction Ca^2+-ATP	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kTrop1	0.08	[μM^−1 * ms^−1]	On rate reaction Ca^2+-troponin C	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kTrop2	0.32	[ms^−1]	Off rate reaction Ca^2+-troponin C	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kParvCa1	0.37	[μM^−1 * ms^−1]	On rate reaction Ca^2+-parvalbumin	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kParvCa2	0.003	[ms^−1]	Off rate reaction Ca^2+-parvalbumin	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kParvMg1	1.05𝐸−04	[μM^−1 * ms^−1]	On rate reaction Mg^2+-parvalbumin	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kParvMg2	0.012	[ms^−1]	Off rate reaction Mg^2+-parvalbumin	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kMitCa1	0.37	[μM^−1 * ms^−1]	On rate reaction Ca^2+-mitochondria	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kMitCa2	0.003	[ms^−1]	Off rate reaction Ca^2+-mitochondria	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kMitMg1	1.05𝐸−04	[μM^−1 * ms^−1]	On rate reaction Mg^2+-mitochondria	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kMitMg2	0.012	[ms^−1]	Off rate reaction Mg^2+-mitochondria	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kCsqn1	0.1	[μM^−1 * ms^−1]	On rate reaction Ca^2+-calsequestrin	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kCsqn2	100	[ms^−1]	Off rate reaction Ca^2+-calsequestrin	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kDye1	0.0864	[μM^−1 * ms^−1]	On rate reaction Ca^2+-Dye	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kDye2	6.05	[ms^−1]	Off rate reaction Ca^2+-Dye	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kCam20	0.01	[ms^−1]	Ca dissociation from CaM (C-terminal)	Saucerman [16]
kCam42	0.5	[ms^−1]	2 Ca dissociation from CaM (N-terminal)	Saucerman [16]
kCam0Boff	1.40𝐸−06	[ms^−1]	CaM dissociation from buffer	Saucerman [16]
kPP1	0.0017	[ms^−1]	Thr287 dephosphorylation	Saucerman [16]
KmPP1	11	[µM]	Km for Thr287 dephosphorylation	Saucerman [16]
kbi	0.0013	[ms^−1]	Ca4CaM dissociation from Pb	Gaertner [20]
kbta	0.018	[---]	Polynomial factor autophosphorylation	Gaertner [20]
kbtb	0.015	[---]	Polynomial factor autophosphorylation	Gaertner [20]
kbtc	0.033	[---]	Polynomial factor autophosphorylation	Gaertner [20]
KF50	8.4	[μM]	Dissociation constant Ca-troponin C from XB𝑛 state	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
NF2	1.68	[---]	Power constant for Ca-troponin C influence on kf1	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
KF502	27	[μM]	Dissociation constant Ca-troponin C from XB𝑤 state	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
NF2	8	[---]	Power constant for Ca-troponin C influence on kf2	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kFm1s	0.0045	[ms^−1]	On rate reaction XB𝑛-XB𝑤	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kFm1	0.045	[ms^−1]	Off rate reaction XB𝑛-XB𝑤	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kF0	1.00𝐸−03	[ms^−1]	Rate second reaction XB𝑛-XB𝑤	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kFg1	0.0169	[ms^−1]	Rate reaction XB𝑠-XB𝑟	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kFg2	0.0337	[ms^−1]	Rate reaction XB𝑟-XB𝑛	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kFm2	0.13	[ms^−1]	On rate reaction XB𝑤-XB𝑠	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/
kFm2s	1	[ms^−1]	Off rate reaction XB𝑤-XB𝑠	http://www.tue.nl/en/publication/ep/p/d/ep-uid/247565/